Psilocybin, the psychoactive compound found in psychedelic mushrooms, is being studied in Phase I–III trials for treatment-resistant depression, major depressive disorder, alcohol use disorder, and end-of-life distress.
| Trial | Drug | Phase | Status | Sponsor | Conditions | Start date |
|---|---|---|---|---|---|---|
| Safety Profile of Psilocybin for Cocaine Use Disorder | Psilocybin | Early Phase 1 | Suspended | University of California, Los Angeles | Cocaine Use Disorder | Feb 1, 2029 |
| Inpatient Buprenorphine Induction With Psilocybin for Opioid Use Disorder | Psilocybin | Phase 2 | Withdrawn | Johns Hopkins University | Opioid Use Disorder | Apr 1, 2027 |
| Group PACBT for Depression | Psilocybin | Phase 2 | Not Yet Recruiting | University of California, Los Angeles | Depression - Major Depressive Disorder, Psilocybin, Cognitive Behavioral Therapy | Jan 1, 2027 |
| Psilocybin Effects on Healthy Aging Biomarkers and Purpose in Life | Psilocybin | Phase 1 | Not Yet Recruiting | Charles Raison | Aging, Longevity, Biomarkers of Aging | Dec 1, 2026 |
| NeuroGuard: Psilocybin Trial for Preventing Chemo-induced Neuropathy | Psilocybin | Phase 2 | Not Yet Recruiting | M.D. Anderson Cancer Center | Psilocybin, Neuropathy | Nov 4, 2026 |
| Neuroplasticity Enhancement From Cognitive Training Reinforced by Psilocybin | Psilocybin | Phase 2 | Not Yet Recruiting | National Institute on Aging (NIA) | Alzheimer's Disease | Oct 1, 2026 |
| Psilocybin for Chronic Pelvic Pain (CPP) in Women: A Pilot Feasibility Study | Psilocybin | Phase 1 | Not Yet Recruiting | Oregon Health and Science University | Chronic Pelvic Pain | Oct 1, 2026 |
| Psilocybin for Treatment of OCD-2 | Psilocybin | Phase 1 / Phase 2 | Not Yet Recruiting | Francisco A Moreno | Obsessive - Compulsive Disorder | Sep 8, 2026 |
| Evaluating the Efficacy of a Vocational Counseling Intervention to Improve Occupational Functioning and Employment Quality Among Veterans With Mental Health and Substance Use Disorders | Psilocybin | N/A | Not Yet Recruiting | VA Office of Research and Development | Unemployment | Sep 1, 2026 |
| Consciousness and Psilocybin Effects on Well-Being: The CoPEWell Study | Psilocybin | Phase 1 | Not Yet Recruiting | University of Wisconsin, Madison | Well-Being, Psychological, Psychedelic Experiences | Sep 1, 2026 |
| The Acute Effects of Psilocybin on Cognition, Memory, and Brain Function | Psilocybin | Phase 1 / Phase 2 | Not Yet Recruiting | Manoj Doss | Healthy | Sep 1, 2026 |
| The Effects of Psilocybin on Social Connectedness | Psilocybin | Phase 1 | Not Yet Recruiting | Yale University | Loneliness, Grief | Aug 31, 2026 |
| Psilocybin With Psychotherapy for Improving Chronic Pain in Cancer Patients Requiring Opioids | Psilocybin | Phase 2 | Not Yet Recruiting | Roswell Park Cancer Institute | Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm | Aug 15, 2026 |
| Psilocybin Microdosing on Cognition, Mood and Quality of Life | Psilocybin | Early Phase 1 | Not Yet Recruiting | Yale University | Psychedelic Microdosing Effects on Mood, Cognition, Subjective Well-being and MRI | Aug 10, 2026 |
| Psilocybin-Assisted Psychotherapy in Treating Irritable Bowel Syndrome (IBS) | Psilocybin | Early Phase 1 | Not Yet Recruiting | NYU Langone Health | IBS - Irritable Bowel Syndrome | Aug 1, 2026 |
| Psilocybin Administration With 5-HT1a Blockade | Psilocybin | Early Phase 1 | Recruiting | Johns Hopkins University | Psychedelic Effects in Healthy Volunteers | Aug 1, 2026 |
| Psilocybin Assisted Psychotherapy for Treatment Resistant Depression and Co-occurring Substance Use Disorder | Psilocybin | Phase 1 / Phase 2 | Not Yet Recruiting | Indiana University | Treatment Resistant Depression, Substance Use Disorders | Aug 1, 2026 |
| Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression | Psilocybin | Phase 3 | Not Yet Recruiting | VA Office of Research and Development | Major Depression | Jul 30, 2026 |
| Mindfulness-based Psilocybin Therapy for PTSD | Psilocybin | Phase 2 | Recruiting | Anthony P King | Post Traumatic Stress Disorder, Depression - Major Depressive Disorder | Jul 1, 2026 |
| Feasibility of Incorporating a Standardized Substance Use Measure With Linked-Brief Intervention Into Routine Psychosocial Care of Adult Childhood Cancer Survivors | Psilocybin | N/A | Recruiting | St. Jude Children's Research Hospital | Survivors of Childhood Cancer, Substance Use | Jul 1, 2026 |
| Psilocybin Efficacy With or Without Pimavanserin Pretreatment | Psilocybin | Phase 1 / Phase 2 | Recruiting | Johns Hopkins University | Mood (Psychological Function), Well Being, Mood, Healthy | Jul 1, 2026 |
| The Efficacy of Psilocybin Therapy for Depression in Parkinson's Disease | Psilocybin | Phase 2 | Recruiting | Yale University | Depression, Parkinson's Disease (PD) | Jul 1, 2026 |
| Psilocybin After Trauma Surgery for Pain | Psilocybin | Phase 1 | Not Yet Recruiting | Trent Emerick | Pain Management, Postoperative Pain | Jul 1, 2026 |
| Psilocybin as a Treatment for Chronic Pain in Smokers | Psilocybin | Early Phase 1 | Not Yet Recruiting | Yale University | Smokers With Chronic Pain | Jul 1, 2026 |
| Study of Psilocybin Under Anesthesia Controlled by EEG | Psilocybin | Phase 2 | Not Yet Recruiting | Stanford University | Major Depression | Jul 1, 2026 |
| Psilocybin as a Novel Therapy for Residual Anhedonia | Psilocybin | Phase 1 | Not Yet Recruiting | NYU Langone Health | Anhedonia, Emotional Blunting | Jul 1, 2026 |
| Psilocybin-Assisted Psychotherapy for the Treatment of Severe Alcohol Use Disorder | Psilocybin | Phase 2 | Not Yet Recruiting | Brigham and Women's Hospital | Alcohol Use Disorder | Jun 15, 2026 |
| A Study of Psychedelics in Healthy Older Adults With Low Well-being | Psilocybin | Phase 1 | Recruiting | Jennifer Mitchell | Anhedonia in Healthy Volunteers, Older Adults (50-90 Years) | Jun 1, 2026 |
| Psilocybin-Assisted Physical Therapy in Chronic Low Back Pain | Psilocybin | Phase 2 | Not Yet Recruiting | Yale University | Chronic Low Back Pain (CLBP), Physical Therapy, Psilocybin | Jun 1, 2026 |
| Psilocybin-Assisted Therapy as a Treatment for Depression | Psilocybin | Phase 2 | Not Yet Recruiting | Washington University School of Medicine | Depression | Jun 1, 2026 |
| Psilocybin-Assisted Therapy | Psilocybin | Phase 2 | Not Yet Recruiting | Emory University | PTSD | Jun 1, 2026 |
| Psilocybin-Assisted Therapy for Sexual Assault-Related PTSD | Psilocybin | Phase 2 | Recruiting | Sunstone Medical | Post Traumatic Stress Disorder, PTSD | May 23, 2026 |
| Group Retreat Psilocybin Therapy for the Treatment of Anxiety and Depression in Patients With Metastatic Solid Tumors or Incurable Hematologic Malignancies | Psilocybin | Phase 2 | Active Not Recruiting | University of Washington | Anxiety, Depression, Hematopoietic and Lymphatic System Neoplasm, Metastatic Malignant Solid Neoplasm | May 19, 2026 |
| Psilocybin Whole Mushroom for the Treatment of Obsessive-compulsive Disorder. | Psilocybin | Phase 1 | Recruiting | Francisco A Moreno | Obsessive-Compulsive Disorder | May 18, 2026 |
| A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend) | Psilocybin | Phase 3 | Recruiting | Definium Therapeutics US, Inc. | Major Depressive Disorder | May 10, 2026 |
| Psilocybin to Treat Depression in Spinal Cord Injury | Psilocybin | Phase 1 / Phase 2 | Recruiting | James J. Peters Veterans Affairs Medical Center | Spinal Cord Injury, Depression - Major Depressive Disorder, Veteran | May 1, 2026 |
| Group Psilocybin-Assisted Therapy for Post-Traumatic Stress Disorder | Psilocybin | Phase 1 | Recruiting | University of New Mexico | PTSD | May 1, 2026 |
| Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant Depression | Psilocybin | N/A | Recruiting | Massachusetts General Hospital | Treatment Resistant Depression (TRD) | Apr 17, 2026 |
| Mystical Experiences Without Psychedelics and How Integration Improves Well-Being in Adults | Psilocybin | N/A | Not Yet Recruiting | Baylor University | Healthy Adult Participants | Apr 1, 2026 |
| Pharmacokinetics and Safety of GH001 Delivered Via a GH001 Aerosol Delivery System in Healthy Subjects | Psilocybin | Phase 1 | Not Yet Recruiting | GH Research Ireland Limited | Healthy Adult | Apr 1, 2026 |
| Safety and Tolerability Trial of Psilocybin in Healthy Older Adults | Psilocybin | Phase 1 | Recruiting | University of Colorado, Denver | Healthy Volunteer, Older Adults (65-85 Years) | Apr 1, 2026 |
| Psilocybin for Prolonged Grief Disorder | Psilocybin | Early Phase 1 | Recruiting | University of Virginia | Prolonged Grief Disorder | Mar 24, 2026 |
| Nen ŨnkUmbi/EdaHiYedo Plus (We Are Here Now Plus): a Multi-level Intervention to Reduce Health Disparities Among American Indian Youth | Psilocybin | N/A | Recruiting | Montana State University | Healthy, Condom Use, Mental Health, Substance Use (Drugs, Alcohol) | Mar 23, 2026 |
| Safety and Preliminary Efficacy of Organic Whole Psilocybin-Containing Mushrooms to Treat Patients Suffering From PTSD | Psilocybin | Phase 1 | Active Not Recruiting | Scottsdale Research Institute | PTSD | Mar 20, 2026 |
| Psychedelic Healing: Adjunct Therapy Harnessing Opened Malleability | Psilocybin | Phase 1 | Recruiting | Johns Hopkins University | Stroke, Chronic Stroke, Intracerebral Haemorrhage, Intracerebral Haemorrhage (ICH), Intracerebral Hemorrhage Basal Ganglia, Ischemic Stroke, Ischemic Stroke and Hemorrhagic Stroke, Hemiparesis After Stroke, Hemiplegia Following Ischemic Stroke, Hemiplegia and Hemiparesis, Hemiplegia and/or Hemiparesis Following Stroke, Middle Cerebral Artery Stroke | Feb 9, 2026 |
| Evaluation of Tirzepatide as an Adjunct to Buprenorphine for the Treatment of Opioid Use Disorder | Psilocybin | Phase 2 | Recruiting | T. John Winhusen, PhD | Opioid Use Disorder, Opioid Use Disorder, Moderate, Opioid Use Disorder, Severe | Jan 29, 2026 |
| Effects of Psilocybin on Speech Fluency, Struggle, and Brain Activity in People Who Stutter | Psilocybin | Phase 2 | Not Yet Recruiting | NYU Langone Health | Stuttering | Jan 15, 2026 |
| RCT of Psilocybin-assisted CBT for Depression | Psilocybin | Phase 1 / Phase 2 | Recruiting | University of California, Los Angeles | Major Depressive Diorder | Jan 5, 2026 |
| Psilocybin-Assisted Therapy for the Treatment of Major Depressive Disorder in Patients With Non-Small Cell Lung Cancer | Psilocybin | Phase 2 | Recruiting | Alan Davis | Lung Non-Small Cell Carcinoma, Unipolar Depression | Jan 1, 2026 |
| Psilocybin for Opioid Use Disorder (OUD) | Psilocybin | Phase 2 | Recruiting | NYU Langone Health | Opioid Use Disorder | Dec 17, 2025 |
| Integrated PTSD and Chronic Pain Treatment | Psilocybin | N/A | Recruiting | Weill Medical College of Cornell University | PTSD, Chronic Pain | Dec 8, 2025 |
| Ketamine-assisted Integrative Treatment for Veterans With Chronic Low Back Pain and Comorbid Depression | Psilocybin | Phase 2 | Recruiting | VA Office of Research and Development | Chronic Low Back Pain, Depression | Dec 3, 2025 |
| A Phase 2A Trial of DT402 for Autism Spectrum Disorder | Psilocybin | Phase 2 | Recruiting | Definium Therapeutics US, Inc. | Autism Spectrum Disorder, ASD | Dec 3, 2025 |
| Investigating the Persisting Effects of a Single Dose of Psilocybin on Structural Plasticity in Healthy Older Adults | Psilocybin | Phase 1 | Recruiting | University of California, Berkeley | Aging | Nov 1, 2025 |
| Augmented Momentary Personal Ecological Risk Evaluation | Psilocybin | N/A | Recruiting | University of Washington | Suicidal Ideation, Self Harm | Sep 25, 2025 |
| Psilocybin-Assisted Therapy for Intergenerational Trauma | Psilocybin | Phase 2 | Recruiting | Rachel Yehuda | Psychological Stress, Depression, Anxiety | Aug 28, 2025 |
| Neurobehavioral Mechanisms of Psilocybin-assisted Treatment for AUD | Psilocybin | Phase 2 | Recruiting | NYU Langone Health | Alcohol Use Disorder | Aug 26, 2025 |
| PRoMiSS: Psilocybin and the Role of Music in Set and Setting | Psilocybin | Phase 1 | Enrolling By Invitation | Johns Hopkins University | Psilocybin, Music Intervention | Aug 12, 2025 |
| The RECAP2 Study: Midazolam and Psilocybin | Psilocybin | Phase 1 | Recruiting | University of Wisconsin, Madison | Psilocybin | Aug 7, 2025 |
| Mindfulness-assisted Psychedelic Therapy | Psilocybin | Phase 2 | Recruiting | University of Southern California | Mental Health | Jul 30, 2025 |
| Phase III Long-term Extension Trial to Assess Safety and Efficacy of CYB003 in MDD (EXTEND) | Psilocybin | Phase 3 | Enrolling By Invitation | Cybin IRL Limited | Major Depressive Disorder | Jul 18, 2025 |
| Acceptability & Safety of Two Sequential Doses of Psilocybin in Bipolar Disorder II Depression and Suicidality | Psilocybin | Phase 2 | Recruiting | The University of Texas Health Science Center, Houston | Bipolar II Disorder, Depression, Bipolar, Suicidality | Jul 7, 2025 |
| Psilocybin or Ketamine for Alcohol Use Disorder: An Active Comparator Trial | Psilocybin | Phase 2 | Recruiting | University of Iowa | Alcohol Use Disorder, Alcohol Dependence, Alcohol Abuse | Jun 12, 2025 |
| Psilocybin With Psychological Support (Psi-PS) for Military Veterans and First Responders With Co-occurring PTSD & Alcohol Use Disorder (AUD) | Psilocybin | Phase 2 | Recruiting | Nathan Brashares Sackett | Alcohol Use Disorder (AUD), PTSD | Jun 1, 2025 |
| Psilocybin With Intracranial Neural Sensing | Psilocybin | Phase 1 | Enrolling By Invitation | Joshua Woolley, MD, PhD | Chronic Pain | Jun 1, 2025 |
| Exploration of Synaptotrophic Effects of Psilocybin in Opioid Use Disorder (OUD) | Psilocybin | Phase 1 | Recruiting | Yale University | Opioid Use Disorder | May 28, 2025 |
| TRIPS - Treatment to Improve Depression and/or Anxiety Using Psilocybin-assisted Psychotherapy in Cancer Survivors | Psilocybin | Phase 2 | Recruiting | M.D. Anderson Cancer Center | Depression, Anxiety, Cancer | May 23, 2025 |
| Mechanistic Studies of Psilocybin in Headache Disorders | Psilocybin | Early Phase 1 | Recruiting | Yale University | Migraine | May 19, 2025 |
| Investigation to Understand and Optimize Psilocybin | Psilocybin | Phase 2 | Recruiting | Charles Raison | Depression | May 13, 2025 |
| Psilocybin Brain Stimulation and Imaging Pilot Study | Psilocybin | Phase 1 | Active Not Recruiting | Johns Hopkins University | Healthy Volunteers | Apr 18, 2025 |
| A Phase 3 Trial of MM120 for Major Depressive Disorder (Emerge) | Psilocybin | Phase 3 | Active Not Recruiting | Definium Therapeutics US, Inc. | Major Depressive Disorder | Apr 14, 2025 |
| Effects of Psilocybin in Patients With Amyotrophic Lateral Sclerosis | Psilocybin | Early Phase 1 | Recruiting | Johns Hopkins University | Amyotrophic Lateral Sclerosis | Apr 9, 2025 |
| Gathering Online for Dialogue and Discussion to Enhance Social Support | Psilocybin | N/A | Recruiting | RTI International | Alcohol Misuse, HIV, Sexually Transmitted Infections, Pre-exposure Prophylaxis | Apr 7, 2025 |
| Psilocybin for Methamphetamine Addiction | Psilocybin | Early Phase 1 | Recruiting | Kevin Murnane | Methamphetamine Use Disorder | Apr 4, 2025 |
| Observational Pilot Study to Explore the Social and Health Impacts of a New Model of Care in Oregon: Psilocybin Services on Alcoholism | Psilocybin | N/A | Active Not Recruiting | Healing Advocacy Fund | Alcohol Use Disorder | Mar 5, 2025 |
| Ketamine-Assisted Recovery for Methamphetamine Use Disorder & HIV | Psilocybin | Phase 2 | Active Not Recruiting | Nicky Mehtani, MD, MPH | Methamphetamine Use Disorder | Mar 4, 2025 |
| Psilocybin With Pimavanserin Compared to Psilocybin Alone for the Treatment of Major Depressive Disorder | Psilocybin | Phase 2 | Recruiting | Icahn School of Medicine at Mount Sinai | Major Depressive Disorder | Feb 25, 2025 |
| Sensing Physiological Symptoms of Opioid Withdrawal and Cravings in Patients With Opioid Use Disorder | Psilocybin | N/A | Recruiting | Spark Biomedical, Inc. | Opioid Withdrawal, Opioid Use Disorder | Feb 19, 2025 |
| Investigation of Psychedelic Effects in Psychoactive Substances | Psilocybin | Phase 1 | Recruiting | Johns Hopkins University | Psychedelic Effects in Healthy Volunteers | Feb 5, 2025 |
| State-Funded Trial Assessing Recovery and Long-Term Impact of Guided Psilocybin for Healing Trauma | Psilocybin | Phase 2 | Recruiting | Baylor College of Medicine | PTSD | Jan 30, 2025 |
| The ENHANCE Study: taVNS and Psilocybin | Psilocybin | Phase 1 | Recruiting | University of Wisconsin, Madison | Healthy, Psychedelic Experiences, Vagus Nerve Stimulation | Jan 27, 2025 |
| Pragmatic Trial of Psilocybin Therapy in Palliative Care | Psilocybin | Phase 2 | Recruiting | Charles S. Grob, M.D. | Demoralization | Jan 19, 2025 |
| Psilocybin-Assisted Therapy for Physician Well-Being and Burnout | Psilocybin | Phase 1 / Phase 2 | Recruiting | University of California, San Diego | Burnout, Burnout, Healthcare Workers | Jan 13, 2025 |
| Psilocybin rTMS for Treatment Resistant Depression | Psilocybin | Phase 2 | Recruiting | University of Texas at Austin | Treatment Resistant Depression, MDD, Major Depressive Disorder, Recurrent Depression, Depression | Jan 10, 2025 |
| A Phase 3 Trial of MM120 for Generalized Anxiety Disorder (Voyage) | Psilocybin | Phase 3 | Active Not Recruiting | Definium Therapeutics US, Inc. | Generalized Anxiety Disorder | Dec 11, 2024 |
| Safety for Home Administration of Microdose Psilocybin Use | Psilocybin | Phase 1 | Recruiting | Johns Hopkins University | Psychedelic Experiences | Dec 6, 2024 |
| Study of Psilocybin Assisted Psychotherapy to Address Fear of Recurrence | Psilocybin | Phase 1 | Recruiting | University of Colorado, Denver | Breast Cancer, Ovarian Cancer | Nov 21, 2024 |
| A Second Psilocybin Group Therapy for the Treatment of Cancer-Related Anxiety in Partial Responders With Metastatic Cancer | Psilocybin | Phase 1 | Completed | University of Washington | Hematopoietic and Lymphatic System Neoplasm, Metastatic Malignant Solid Neoplasm | Nov 19, 2024 |
| Study of Psilocybin for Anorexia in Young Adults | Psilocybin | Phase 2 | Recruiting | Marissa Raymond-Flesch, MD, MPH | Anorexia Nervosa | Nov 18, 2024 |
| Psilocybin-assisted Treatment for Cannabis Use Disorder | Psilocybin | Phase 1 | Recruiting | Johns Hopkins University | Cannabis Use Disorder | Nov 8, 2024 |
| Investigating the Interaction of Psilocybin and Context of Its Administration in Healthy Volunteers | Psilocybin | Phase 2 | Recruiting | Robin Carhart-Harris, PhD, MA | Healthy Participants With Lower-than-average Mental Well-being | Oct 20, 2024 |
| Open-Label Psilocybin Study in Transdiagnostic Population | Psilocybin | Phase 1 | Recruiting | Yale University | Transdiagnostic, Depression - Major Depressive Disorder, Anxiety, PTSD Symptoms, PTSD, Substance Use, Substance Use Disorder (SUD), OCD | Oct 17, 2024 |
| Optimizing Microdosing and Meditation | Psilocybin | N/A | Withdrawn | National University of Natural Medicine | Meditation, Microdosing | Oct 1, 2024 |
| Psilocybin in Cancer Pain Study | Psilocybin | Phase 2 | Recruiting | Yvan Beaussant, MD, MSci | Opioid-Related Disorders, Pain Management, Pain Management and Care, Advanced Cancer, Advanced Cancers | Sep 23, 2024 |
| The Effects of Psilocybin on Self-Focus and Self-Related Processing in Major Depressive Disorder | Psilocybin | Phase 3 | Recruiting | Sharmin Ghaznavi | Major Depressive Disorder | Sep 10, 2024 |
| Psilocybin Therapy for Depression in Parkinson's Disease | Psilocybin | Phase 2 | Recruiting | Joshua Woolley, MD, PhD | Parkinson Disease, Depression | Aug 19, 2024 |
| Low-Income Group Psilocybin Assisted Therapy for Depression | Psilocybin | N/A | Completed | Matthew Hicks | Depression | Aug 1, 2024 |
| Psilocybin for Treatment-Resistant Depression | Psilocybin | Phase 2 | Completed | University of Colorado, Denver | Major Depressive Disorder, Anhedonia, Treatment Resistant Depression | Jul 8, 2024 |
| A Study of Psilocybin for PTSD | Psilocybin | Phase 1 | Active Not Recruiting | Johns Hopkins University | Post Traumatic Stress Disorder | Jun 7, 2024 |
| Couples Motivational Interviewing to Reduce Drug Use and HIV Risk in Vulnerable Male Couples | Psilocybin | N/A | Recruiting | Hunter College of City University of New York | Substance Use, HIV Infections | May 25, 2024 |
| Ketamine-assisted Therapy for Advanced GI Cancer | Psilocybin | Phase 4 | Terminated | Brian Anderson, MD | Pancreatic Ductal Adenocarcinoma, Pain, Acute, Gastrointestinal Cancers, Demoralization | May 17, 2024 |
| Building Social and Structural Connections for the Prevention of Opioid Use Disorder Among Youth Experiencing Homelessness | Psilocybin | N/A | Recruiting | Ohio State University | Opioid Use Disorder, Dual Diagnosis, Housing Problems, Mental Disorder in Adolescence, Risk Behavior, Homelessness | May 6, 2024 |
| Mindful Self-Compassion to Address PTSD and Substance Use in Unhoused Women | Psilocybin | N/A | Completed | University of California, Los Angeles | Posttraumatic Stress Disorder (PTSD), Anxiety, Depression - Major Depressive Disorder | May 5, 2024 |
| Psilocybin in Chronic Low Back Pain and Depression | Psilocybin | Phase 1 | Recruiting | Johns Hopkins University | Chronic Low-back Pain, Depression | Apr 22, 2024 |
| Psilocybin-Assisted Therapy in Treatment-Resistant Depression | Psilocybin | Phase 3 | Active Not Recruiting | University of North Carolina, Chapel Hill | Refractory Depression, Treatment Resistant Depression | Apr 19, 2024 |
| Psilocybin-Assisted Psychotherapy in Patients With Advanced Cancer on Maintenance Therapy | Psilocybin | Phase 2 | Recruiting | M.D. Anderson Cancer Center | Depression, Anxiety, Psilocybin-Assisted Psychotherapy, Advanced Cancer | Apr 16, 2024 |
| Psilocybin for Major Depressive Disorder (MDD) | Psilocybin | Phase 3 | Active Not Recruiting | Usona Institute | Depressive Disorder, Major | Mar 13, 2024 |
| Investigating the Mechanisms of the Effects of Psilocybin on Visual Perception and Visual Representations in the Brain | Psilocybin | Phase 1 | Recruiting | University of California, Berkeley | Perception Disorders | Mar 8, 2024 |
| Outpatient Buprenorphine Induction With Psilocybin for Opioid Use Disorder | Psilocybin | Phase 2 | Recruiting | Johns Hopkins University | Opioid Use Disorder | Feb 8, 2024 |
| Psilocybin-Assisted vs Ketamine-Assisted Psychotherapy for Alcohol Use Disorder | Psilocybin | Phase 2 | Active Not Recruiting | Peggy C Nopoulos | Alcohol Use Disorder | Feb 2, 2024 |
| Assessment of Psilocybin (TRP-8802) in Concert With Psychotherapy in Patients With Irritable Bowel Syndrome (IBS) | Psilocybin | Phase 2 | Active Not Recruiting | TRYP Therapeutics | Irritable Bowel Syndrome | Jan 17, 2024 |
| Psilocybin Therapy for Chronic Low Back Pain | Psilocybin | Phase 1 / Phase 2 | Active Not Recruiting | Joshua Woolley, MD, PhD | Chronic Low-back Pain | Dec 1, 2023 |
| Consciousness, Psilocybin, and Well-Being | Psilocybin | Phase 1 | Completed | University of Wisconsin, Madison | Healthy, Psychedelic Experiences, Sleep | Nov 7, 2023 |
| 5-HT2A Agonist Psilocybin in the Treatment of Tobacco Use Disorder | Psilocybin | Phase 2 | Recruiting | Johns Hopkins University | Tobacco Use Disorder | Nov 1, 2023 |
| Psilocybin in Co-occuring Major Depressive Disorder and Borderline Personality Disorder | Psilocybin | Phase 2 | Completed | University of Chicago | Borderline Personality Disorder, Major Depressive Disorder | Nov 1, 2023 |
| Psilocybin-facilitated Treatment for Chronic Pain | Psilocybin | Early Phase 1 | Recruiting | University of Alabama at Birmingham | Fibromyalgia, Primary | Nov 1, 2023 |
| Two Doses of Psilocybin for the Treatment of MDD in Adults With Cancer | Psilocybin | Phase 2 | Active Not Recruiting | Sunstone Medical | Cancer, Major Depressive Disorder | Oct 23, 2023 |
| Open-label Study to Assess the Safety and Efficacy of Psilocybin With Psychotherapy in Adult Participants With Fibromyalgia | Psilocybin | Phase 2 | Completed | Kevin Boehnke | Fibromyalgia | Sep 27, 2023 |
| Northwest Therapies Trauma Psilocybin Study Compassionate Use Study | Psilocybin | Phase 1 | Unknown | NWTraumatherapies | Trauma, Nervous System | Sep 3, 2023 |
| Test of the Better Together Intervention | Psilocybin | N/A | Completed | Johns Hopkins Bloomberg School of Public Health | Substance Use | Sep 1, 2023 |
| Exploratory Study of Low Dose Psilocybin | Psilocybin | Early Phase 1 | Withdrawn | University of Alabama at Birmingham | Demoralization | Aug 15, 2023 |
| Alcohol Misuse, Gut Microbial Dysbiosis and PrEP Care Continuum: Application and Efficacy of SBIRT Intervention | Psilocybin | N/A | Recruiting | Shirish S Barve | Alcohol Use Disorder, Risk Behavior, Health, Dysbiosis, HIV Infections | Aug 1, 2023 |
| Neural and Physiological Correlates of Psychedelic Sub-states | Psilocybin | Phase 1 | Active Not Recruiting | Robin Carhart-Harris, PhD, MA | Psychedelic Experiences, Neuroimaging, Healthy Volunteers | Jul 31, 2023 |
| Effects of Repeated Psilocybin Dosing in OCD | Psilocybin | Phase 1 | Active Not Recruiting | Yale University | Obsessive-Compulsive Disorder | Jul 20, 2023 |
| PET Synaptogenesis After Psilocybin In DEpression Recovery | Psilocybin | Phase 2 | Withdrawn | Washington University School of Medicine | Major Depressive Disorder, Anhedonia | Jul 1, 2023 |
| Psilocybin-Assisted Therapy for the Treatment of Cancer-Related Anxiety in Patients With Metastatic Cancer | Psilocybin | Phase 1 / Phase 2 | Completed | University of Washington | Hematopoietic and Lymphatic System Neoplasm, Metastatic Malignant Solid Neoplasm | Jun 27, 2023 |
| Psilocybin-assisted CBT for Depression | Psilocybin | Phase 1 | Completed | University of California, Los Angeles | Major Depressive Disorder | Jun 27, 2023 |
| Peer Recovery to Improve Polysubstance Use and Mobile Telemedicine Retention | Psilocybin | N/A | Recruiting | University of Maryland, College Park | Polysubstance Addiction, Opioid Medication Assisted Treatment, Treatment Adherence, Retention in Care, Substance-Related Disorders | Jun 15, 2023 |
| Bioavailability Study of Psilocybin in Normal Adults | Psilocybin | Phase 1 | Withdrawn | University of Wisconsin, Madison | Healthy | Jun 1, 2023 |
| Reducing Drug Use in Justice-Involved Emerging Adults | Psilocybin | N/A | Completed | Chestnut Health Systems | Substance-Related Disorders | May 26, 2023 |
| Psilocybin Therapy in Advanced Cancer | Psilocybin | Phase 2 / Phase 3 | Recruiting | NYU Langone Health | Advanced Cancer | May 24, 2023 |
| Telemedicine for Unhealthy Alcohol Use in Persons Living With HIV Using CETA | Psilocybin | N/A | Active Not Recruiting | University of Alabama at Birmingham | Hiv, Alcohol Problem | May 4, 2023 |
| Effectiveness of an Evidence-based Stepped Care System for Alcohol and Other Drug Use Problems Among Congolese Refugees in Zambia | Psilocybin | N/A | Completed | Columbia University | Alcohol and Substance-Related Mental Disorders | Apr 26, 2023 |
| Palliadelic Treatment to Reduce Psychological Distress in Persons With Advanced Gastrointestinal Cancers | Psilocybin | Phase 1 | Active Not Recruiting | University of Nebraska | Pancreas Cancer, Biliary Tract Cancer, Psychological Distress, Gastrointestinal Cancer | Apr 10, 2023 |
| Evaluating the Efficacy of Annual CHTC Retesting Among Male Couples at High Risk of HIV Infection | Psilocybin | N/A | Enrolling By Invitation | Hunter College of City University of New York | HIV Infections | Apr 1, 2023 |
| Study of the Safety and Feasibility of Psilocybin in Adults With Methamphetamine Use Disorder | Psilocybin | Phase 1 | Terminated | University of Wisconsin, Madison | Methamphetamine Use Disorder, Substance-Related Disorders, Chemically-Induced Disorders, Substance Use Disorders, Stimulant-Use Disorder | Mar 3, 2023 |
| Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRD | Psilocybin | Phase 3 | Active Not Recruiting | COMPASS Pathways | Treatment Resistant Depression | Feb 14, 2023 |
| A Phase II, Multicentre, Randomised, Double-blind, Controlled Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of COMP360 in Participants With Recurrent Major Depressive Disorder | Psilocybin | Phase 2 | Active Not Recruiting | COMPASS Pathways | Major Depressive Disorder | Jan 30, 2023 |
| Efficacy, Safety, and Tolerability of COMP360 in Participants With TRD | Psilocybin | Phase 3 | Active Not Recruiting | COMPASS Pathways | Treatment Resistant Depression | Jan 19, 2023 |
| PAPR: PAP + MBSR for Front-line Healthcare Provider COVID-19 Related Burnout | Psilocybin | Phase 1 | Completed | University of Utah | Depression, Burnout, Professional | Jan 2, 2023 |
| Psilocybin for the Treatment of Veterans With Post-Traumatic Stress Disorder | Psilocybin | Phase 2 | Active Not Recruiting | Ohio State University | PTSD, Stress Disorders, Traumatic, Stress Disorders, Post-Traumatic, Trauma and Stressor Related Disorders, Mental Disorder | Jan 1, 2023 |
| Effects of Psilocybin in Obsessive Compulsive Disorder | Psilocybin | Early Phase 1 | Active Not Recruiting | Johns Hopkins University | Obsessive-Compulsive Disorder | Nov 28, 2022 |
| Psilocybin Combined With Multidisciplinary Palliative Care in Demoralized Cancer Survivors With Chronic Pain | Psilocybin | Phase 1 | Completed | Emory University | Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm | Nov 1, 2022 |
| Psilocybin-assisted Therapy for Phantom Limb Pain | Psilocybin | Phase 1 | Completed | University of California, San Diego | Phantom Limb Pain | Oct 3, 2022 |
| The Effects of Psilocybin on Self-Focus and Self-Related Processing in Treatment Resistant MDD | Psilocybin | Phase 2 | Withdrawn | Massachusetts General Hospital | Treatment-Resistant Major Depressive Disorder | Sep 15, 2022 |
| Psilocybin-Enhanced Psychotherapy for Methamphetamine Use Disorder | Psilocybin | Phase 1 / Phase 2 | Active Not Recruiting | Portland VA Research Foundation, Inc | Amphetamine-Related Disorders | Jul 7, 2022 |
| Effects of Psilocybin in Post-Treatment Lyme Disease | Psilocybin | Phase 1 | Completed | Johns Hopkins University | Post-Treatment Lyme Disease, Chronic Lyme Disease, Lyme Disease, Chronic | Jul 1, 2022 |
| An Evaluation of Psilocybin's Effect on Cardiac Repolarization and the Effect of Food on Psilocybin's Pharmacokinetics | Psilocybin | Phase 1 | Completed | Usona Institute | QTc Interval, Pharmacokinetics | Jun 22, 2022 |
| The Safety and Tolerability of COMP360 in Participants With Post-traumatic Stress Disorder | Psilocybin | Phase 2 | Completed | COMPASS Pathways | Post Traumatic Stress Disorder | Jun 10, 2022 |
| Delivering Transcutaneous Auricular Neurostimulation to Improve Relapse Prevention in Opioid Use Disorder | Psilocybin | N/A | Completed | Spark Biomedical, Inc. | Opioid-use Disorder, Opioid Withdrawal | May 27, 2022 |
| Comparing the Effects of Psilocin and Psilocybin in Healthy Adults | Psilocybin | Phase 1 | Active Not Recruiting | University of California, San Francisco | Healthy | May 26, 2022 |
| Addressing Risk Through Community Treatment for Infectious Disease and Opioid Use Disorder Now (ACTION) Among Justice-involved Populations | Psilocybin | N/A | Completed | Yale University | Opioid Use Disorder, Infectious Disease, Risk Reduction Behavior, Substance Use, Substance Abuse, Stimulant Use Disorder | Mar 31, 2022 |
| Examining the Feasibility and Acceptability of a Tailored Version of a Mindfulness-Based Intervention (MBI) Among Youth Experiencing Homelessness (YEH) | Psilocybin | N/A | Completed | The University of Texas Health Science Center, Houston | Stress, Emotional | Mar 28, 2022 |
| The Safety and Efficacy of Psilocybin in Patients With Treatment-resistant Depression and Chronic Suicidal Ideation | Psilocybin | Phase 2 | Completed | Sheppard Pratt Health System | Treatment Resistant Depression, Suicidal Ideation | Mar 28, 2022 |
| Evaluation of Psilocybin (TRP-8802) in the Treatment of Binge Eating Disorder | Psilocybin | Phase 2 | Completed | TRYP Therapeutics | Binge Eating Disorder | Mar 16, 2022 |
| Pilot Study of Psilocybin-Assisted Therapy for Demoralization in Patients Receiving Hospice Care | Psilocybin | Phase 2 | Completed | Yvan Beaussant, MD, MSci | Hospice, Psilocybin, Demoralization, Terminal Illness, Cancer-related Problem/Condition, Psychotherapy, Terminal Cancer, Cancer Terminal | Mar 9, 2022 |
| Frontline Clinician Psilocybin Study | Psilocybin | Phase 3 | Completed | University of Washington | Burnout, Caregiver, Burnout, Professional, COVID-19, Depression, Post Traumatic Stress Disorder, Moral Injury | Mar 3, 2022 |
| Effects of Psilocybin on Electrophysiology and the Dynamic Content of Thought | Psilocybin | Phase 1 / Phase 2 | Recruiting | Johns Hopkins University | Healthy | Mar 3, 2022 |
| Psilocybin Therapy for Depression in Bipolar II Disorder | Psilocybin | Phase 2 | Active Not Recruiting | University of California, San Francisco | Bipolar II Disorder | Jan 28, 2022 |
| Establishing a Diagnostic and Therapeutic Index in Autism Spectrum Disorder (ASD) and Fragile X Syndrome | Psilocybin | N/A | Unknown | Nova Mentis Life Science Corp | Autism Spectrum Disorder, Fra(X) Syndrome | Nov 1, 2021 |
| Expanding the Potential of Couples HIV Testing: Adjunct Modules to Reduce Drug Use Among Vulnerable Male Couples | Psilocybin | N/A | Active Not Recruiting | Hunter College of City University of New York | Substance Use, HIV Infections | Oct 13, 2021 |
| Study of Psilocybin Enhanced Group Psychotherapy in Patients With Cancer | Psilocybin | Early Phase 1 | Completed | University of Utah | Cancer | Oct 4, 2021 |
| Visual Surround Suppression and Perceptual Expectation Under Psilocybin | Psilocybin | Phase 1 | Terminated | University of Minnesota | Perception Disturbance, Visual Suppression, Psychedelic Experiences | Aug 30, 2021 |
| Psilocybin Therapy for Depression and Anxiety in Parkinson's Disease | Psilocybin | Phase 2 | Completed | Joshua Woolley, MD, PhD | Parkinson Disease, Depression, Anxiety | Aug 15, 2021 |
| Repeat Dosing of Psilocybin in Migraine Headache | Psilocybin | Phase 1 | Completed | Yale University | Migraine Headache | Aug 10, 2021 |
| A Phase 3 Study of NE3107 in Probable Alzheimer's Disease | Psilocybin | Phase 3 | Completed | BioVie Inc. | Alzheimer Disease | Aug 5, 2021 |
| Pilot Test of Parent-Focused Cannabis-Related Actions and Practices Intervention for Adolescent Marijuana Abuse | Psilocybin | N/A | Completed | Oregon Research Institute | Cannabis Use Disorder, Mild, Cannabis Use Disorder, Moderate | Jun 1, 2021 |
| Precision Functional Brain Mapping in Psilocybin | Psilocybin | Early Phase 1 | Completed | Washington University School of Medicine | Psilocybin | Jun 1, 2021 |
| Pilot RECAP Study in Healthy Volunteers | Psilocybin | Phase 1 | Completed | University of Wisconsin, Madison | Psychedelic Experiences, Amnesia | May 21, 2021 |
| Evaluation of Psilocybin in Anorexia Nervosa: Safety and Efficacy | Psilocybin | Phase 2 | Completed | University of California, San Diego | Anorexia Nervosa | May 1, 2021 |
| Psilocybin Treatment of Major Depressive Disorder With Co-occurring Alcohol Use Disorder | Psilocybin | Phase 2 | Active Not Recruiting | Johns Hopkins University | Major Depressive Disorder, Alcohol Use Disorder | Apr 14, 2021 |
| Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's Disease | Psilocybin | Early Phase 1 | Recruiting | Johns Hopkins University | Depressive Symptoms, Depression, Alzheimer Disease, Mild Cognitive Impairment | Mar 24, 2021 |
| An Open Label Study of the Safety and Efficacy of Psilocybin in Participants With Treatment-Resistant Depression (P-TRD) | Psilocybin | Phase 2 | Active Not Recruiting | Sheppard Pratt Health System | Treatment Resistant Depression | Mar 1, 2021 |
| The Safety and Efficacy of Psilocybin in Participants With Type 2 Bipolar Disorder (BP-II) Depression. | Psilocybin | Phase 2 | Unknown | Sheppard Pratt Health System | Treatment Resistant Depression | Mar 1, 2021 |
| Safety and Efficacy of Psilocybin for Body Dysmorphic Disorder | Psilocybin | Phase 2 | Completed | New York State Psychiatric Institute | Body Dysmorphic Disorders | Feb 26, 2021 |
| iSTART: A Campus & Community Initiative for Services in Tec-health | Psilocybin | N/A | Completed | California State University, Northridge | Substance Use, Binge Drinking, Marijuana Use, Alcohol Drinking, Prescription Opioid Misuse, Illicit Drug Use | Feb 20, 2021 |
| Pilot Trial of Visual Healing® in Psilocybin-assisted Therapy for Alcohol Use Disorder | Psilocybin | Phase 2 | Active Not Recruiting | Keith Heinzerling | Alcohol Use Disorder | Feb 18, 2021 |
| Adjunctive Effects of Psilocybin and a Formulation of Buprenorphine | Psilocybin | Phase 1 | Recruiting | University of Wisconsin, Madison | Opioid Use Disorder | Jan 13, 2021 |
| The Safety and Efficacy of Psilocybin in Cancer Patients With Major Depressive Disorder | Psilocybin | Phase 2 | Unknown | Maryland Oncology Hematology, PA | Major Depressive Disorder | Sep 1, 2020 |
| Clinical Evaluation of Safety and Tolerability of KDR2-2 Eye Drops in Healthy Volunteers With Pharmacokinetic Assessment | Psilocybin | Phase 1 | Unknown | Guangzhou HuiBoRui Biological Pharmaceutical Technology Co. Ltd | Corneal Neovascularization | Aug 26, 2020 |
| The Safety and Efficacy Of Psilocybin as an Adjunctive Therapy in Participants With Treatment Resistant Depression | Psilocybin | Phase 2 | Completed | COMPASS Pathways | Treatment Resistant Depression | Aug 10, 2020 |
| Long Term Follow Up Study to COMP 001 And COMP 003 Trials (P-TRD LTFU) | Psilocybin | N/A | Completed | COMPASS Pathways | Treatment Resistant Depression | Jul 20, 2020 |
| Therapy and Peer Support for Patients Taking Medication for Opioid Use Disorder | Psilocybin | N/A | Active Not Recruiting | Philadelphia College of Osteopathic Medicine | Opioid Use Disorder | Jul 15, 2020 |
| PSIL201 Long-term Follow-up Study: Psilocybin or Niacin / Major Depressive Disorder | Psilocybin | N/A | Terminated | Usona Institute | Major Depressive Disorder | Jun 30, 2020 |
| A Retrospective Effectiveness Trial of Ketamine-Assisted Psychotherapy in Adult Patients Coping With Mental Health | Psilocybin | Phase 4 | Completed | Field Trip Health | Depression, Anxiety, Post Traumatic Stress Disorder | Mar 13, 2020 |
| Patient Doctor Lies | Psilocybin | N/A | Completed | University of Utah | Patient Lying, Privacy Statements, Risk Statements, Benefit Statements, Patient Lie Detection | Feb 12, 2020 |
| Social Media Intervention for Cannabis Use in Emerging Adults | Psilocybin | N/A | Completed | University of Michigan | Cannabis Use | Feb 3, 2020 |
| A Study of Psilocybin for Major Depressive Disorder (MDD) | Psilocybin | Phase 2 | Completed | Usona Institute | Depressive Disorder, Major | Jan 23, 2020 |
| Y2Prevent: Preventing Drug Use and HIV Through Empowerment, Social Support and Mentorship (Y2P) | Psilocybin | N/A | Completed | Children's Hospital Los Angeles | HIV, Drug Use | Jan 22, 2020 |
| Effects of Psilocybin in Anorexia Nervosa | Psilocybin | Phase 1 | Completed | Johns Hopkins University | Anorexia Nervosa | Aug 26, 2019 |
| Effects of Drugs on Responses to Brain and Emotional Processes | Psilocybin | Early Phase 1 | Completed | University of Chicago | Autism Spectrum Disorder, Healthy | Aug 8, 2019 |
| HIV+ Substance Users Released From Jail | Psilocybin | N/A | Completed | University of Texas Southwestern Medical Center | HIV/AIDS, Substance Use Disorders | May 29, 2019 |
| Mood Effects of Serotonin Agonists Extended | Psilocybin | Phase 1 | Completed | University of Chicago | Healthy | Apr 20, 2019 |
| Effects of Psilocybin in Concussion Headache | Psilocybin | Phase 1 | Terminated | Yale University | Post-Traumatic Headache | Mar 28, 2019 |
| The Safety and Efficacy of Psilocybin in Participants With Treatment Resistant Depression | Psilocybin | Phase 2 | Completed | COMPASS Pathways | Treatment Resistant Depression | Mar 1, 2019 |
| Psilocybin for Treatment of Obsessive Compulsive Disorder | Psilocybin | Phase 1 | Completed | University of Arizona | Obsessive-compulsive Disorder (OCD) | Jan 2, 2019 |
| Efficacy of Psilocybin in OCD: a Double-Blind, Placebo-Controlled Study. | Psilocybin | Phase 1 | Completed | Yale University | Obsessive-Compulsive Disorder | Nov 13, 2018 |
| Project PRIDE (Promoting Resilience In Discriminatory Environments) | Psilocybin | N/A | Completed | University of Houston | Human Immunodeficiency Virus, Sexually Transmitted Infections, Anxiety, Depression, Substance Use Disorders | Nov 9, 2018 |
| Effectiveness & Implementation of a Behavioral Intervention for Adherence and Substance Use in HIV Care in South Africa | Psilocybin | N/A | Completed | University of Maryland, College Park | Human Immunodeficiency Virus, Alcohol-Related Disorders, Drug Use | Jul 30, 2018 |
| Mood Effects of Serotonin Agonists | Psilocybin | Phase 1 | Completed | University of Chicago | Healthy | May 1, 2018 |
| Psilocybin - Induced Neuroplasticity in the Treatment of Major Depressive Disorder | Psilocybin | Phase 1 | Active Not Recruiting | Yale University | Major Depressive Disorder | Feb 27, 2018 |
| Psilocybin-assisted Group Therapy for Demoralization in Long-term AIDS Survivors | Psilocybin | Phase 1 | Completed | Joshua Woolley | Distress, Depression, Grief | Jan 5, 2018 |
| Harnessing Placebo Effects in Methadone Treatment | Psilocybin | N/A | Completed | University of Maryland, Baltimore | Opioid-use Disorder, Opioid-Related Disorders | Dec 5, 2017 |
| Project MADD - NIH Underage DUI and Ride | Psilocybin | N/A | Completed | Penn State University | Underage Drinking, Driving Under the Influence, Drinking, Teen | Nov 17, 2017 |
| Psilocybin for the Treatment of Migraine Headache | Psilocybin | Phase 1 | Completed | Yale University | Migraine Headache | Nov 1, 2017 |
| Developing SUPPORT, a Community-Driven, Recovery-Oriented System of Care | Psilocybin | N/A | Completed | Indiana University | Substance Use | Oct 23, 2017 |
| Increasing Caregiver Engagement in Juvenile Drug Courts | Psilocybin | N/A | Completed | Medical University of South Carolina | Substance Abuse | Oct 13, 2017 |
| Pilot Study Comparing Two Versions of Group Cognitive-behavioral Indicated Prevention Programs | Psilocybin | N/A | Completed | Oregon Research Institute | Depressive Symptoms | Oct 10, 2017 |
| Effects of Psilocybin in Major Depressive Disorder | Psilocybin | Phase 2 | Completed | Johns Hopkins University | Major Depressive Disorder | Aug 10, 2017 |
| Persisting Effects of Psilocybin | Psilocybin | Phase 1 / Phase 2 | Completed | Johns Hopkins University | Healthy | Jul 1, 2017 |
| Iwin: Individual Well-Being Navigator | Psilocybin | N/A | Completed | Pro-Change Behavior Systems | Other Drug Substance Abuse | Jun 17, 2017 |
| Adolescents With Substance Use Disorders Transitioníng From Residential Treatment to the Community | Psilocybin | N/A | Completed | Brown University | Substance Use, Adolescent Behavior | Apr 1, 2017 |
| IMPAACT 2002: Cognitive Behavioral Therapy and Medication Management for Treatment of Depression in US Youth With HIV | Psilocybin | N/A | Completed | International Maternal Pediatric Adolescent AIDS Clinical Trials Group | HIV, Depression | Mar 6, 2017 |
| Pilot Study of the Safety and Efficacy of Four Different Potencies of Smoked Marijuana in 76 Veterans With PTSD | Psilocybin | Phase 2 | Completed | Multidisciplinary Association for Psychedelic Studies | Posttraumatic Stress Disorder | Jan 2, 2017 |
| Psilocybin for the Treatment of Cluster Headache | Psilocybin | Phase 1 | Completed | Yale University | Cluster Headache | Dec 5, 2016 |
| Buprenorphine and Substance Abuse Services for Prescription Opioid Dependence | Psilocybin | N/A | Completed | Kaiser Permanente | Opiate Substitution Treatment | Dec 1, 2015 |
| Motivational Coaching to Enhance Mental Health Engagement in Rural Veterans | Psilocybin | N/A | Completed | VA Office of Research and Development | Mental Health, Rural Health, Veterans Health | Oct 1, 2015 |
| Implementation Research for Vulnerable Women in South Africa | Psilocybin | N/A | Completed | RTI International | HIV, Substance Abuse | Sep 1, 2015 |
| Understanding Substance Use and Incident HIV/STI Among Young Black MSM | Psilocybin | N/A | Completed | Emory University | HIV, Substance Abuse | Jul 1, 2015 |
| Psilocybin-facilitated Treatment for Cocaine Use | Psilocybin | Phase 2 | Completed | University of Alabama at Birmingham | Cocaine-Related Disorders | May 1, 2015 |
| The Effects of Psilocybin-Facilitated Experience on the Psychology and Effectiveness of Religious Professionals | Psilocybin | Phase 1 | Completed | NYU Langone Health | Religious or Spiritual Problem | Apr 1, 2015 |
| Effects of Psilocybin-facilitated Experience on the Psychology and Effectiveness of Professional Leaders in Religion | Psilocybin | Phase 1 | Completed | Johns Hopkins University | Healthy | Mar 1, 2015 |
| Pilot Study of Entacapone for Methamphetamine Abuse | Psilocybin | Early Phase 1 | Completed | Oregon Health and Science University | Methamphetamine Dependence | Jun 1, 2014 |
| A Double-Blind Trial of Psilocybin-Assisted Treatment of Alcohol Dependence | Psilocybin | Phase 2 | Completed | NYU Langone Health | Alcohol Dependence | Jun 1, 2014 |
| Young Women's Health CoOp (Cooperative) in Cape Town | Psilocybin | N/A | Completed | RTI International | HIV, Substance Abuse | May 1, 2014 |
| Effects of Psilocybin on Behavior, Psychology and Brain Function in Long-term Meditators | Psilocybin | Phase 1 | Completed | Johns Hopkins University | Healthy | May 1, 2014 |
| Effects of Hallucinogens and Other Drugs on Mood and Performance | Psilocybin | Phase 1 | Completed | Johns Hopkins University | Healthy | Apr 1, 2014 |
| Substance Use and Sexual Risk Reduction Intervention for Homeless Youth | Psilocybin | N/A | Completed | RAND | Substance Use, Sexual Risk Behavior | Jan 1, 2014 |
| Pilot Study: Effects of Psilocybin on Behavior, Psychology and Brain Function in Long-term Meditators | Psilocybin | Phase 1 | Completed | Johns Hopkins University | Psilocybin, Hallucinogens, Pharmacologic Actions, Central Nervous System Agents, Therapeutic Uses, Psychotropic Drugs | May 1, 2013 |
| A Web-Based Intervention to Prevent Drug Abuse Among Adolescent Girls | Psilocybin | N/A | Completed | Columbia University | Drug Abuse Prevention | Mar 1, 2013 |
| Preventing Drug Abuse Among Hispanic Adolescents | Psilocybin | N/A | Completed | Columbia University | Drug Abuse | Sep 1, 2012 |
| Family and Adolescent Motivational Incentives for Leveraging Youth | Psilocybin | N/A | Completed | Oregon Research Institute | Substance-Related Disorders | Jul 1, 2012 |
| Integrating Substance Abuse Assessment & Intervention in Primary Care Settings | Psilocybin | N/A | Completed | Treatment Research Institute | Drug Use, Alcohol Use | Jun 1, 2012 |
| A Study to Assess the Abuse Potential of Hydrocodone Extended-Release Tablet in Recreational Opioid Users | Psilocybin | Phase 1 | Completed | Cephalon | Drug Abuse | Mar 1, 2012 |
| Psilocybin-Assisted Psychotherapy for Anxiety in People With Stage IV Melanoma | Psilocybin | Phase 2 | Withdrawn | Multidisciplinary Association for Psychedelic Studies | Anxiety, Stage IV Melanoma | Jan 1, 2012 |
| Effects and Therapeutic Potential of Psilocybin in Alcohol Dependence | Psilocybin | Phase 2 | Completed | University of New Mexico | Alcohol Dependence | Jan 1, 2012 |
| Safety Study of Oxycodone Hydrochloride and Naltrexone Hydrochloride Extended-Release Capsules in Subjects With Moderate to Severe Chronic Noncancer Pain | Psilocybin | Phase 3 | Completed | Pfizer | Chronic Noncancer Pain | Dec 1, 2010 |
| Conversion to Embeda With Rescue Trial | Psilocybin | Phase 4 | Terminated | Pfizer | Chronic Disease, Pain | Aug 1, 2010 |
| Impact of Group Motivational Interviewing and In-Home-Messaging-Devices for Dually Diagnosed Veterans | Psilocybin | N/A | Completed | VA Office of Research and Development | Alcohol Dependence, Dual Diagnosis, Drug Dependence | May 3, 2010 |
| Trial of Activated Marrow Infiltrating Lymphocytes Alone or in Conjunction With an Allogeneic Granulocyte Macrophage Colony-stimulating Factor (GM-CSF)-Based Myeloma Cellular Vaccine in the Autologous Transplant Setting in Multiple Myeloma | Psilocybin | Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Multiple Myeloma | Jan 15, 2010 |
| Psilocybin and Spiritual Practice | Psilocybin | Phase 1 | Completed | Johns Hopkins University | Healthy | Aug 1, 2009 |
| Clinical Pharmacology of MDA [3,4-methylenedioxyamphetamine] | Psilocybin | N/A | Completed | California Pacific Medical Center Research Institute | Healthy | Jan 1, 2009 |
| Psilocybin-facilitated Smoking Cessation Treatment: A Pilot Study | Psilocybin | N/A | Completed | Johns Hopkins University | Nicotine Dependence | Sep 1, 2008 |
| Caffeine and Cocaine | Psilocybin | Phase 1 / Phase 2 | Completed | Virginia Commonwealth University | Cocaine Dependence | Apr 1, 2008 |
| Activated White Blood Cells With ASCT for Newly Diagnosed Multiple Myeloma | Psilocybin | Phase 1 / Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Multiple Myeloma and Plasma Cell Neoplasm | Nov 1, 2007 |
| Psychopharmacology of Psilocybin in Cancer Patients | Psilocybin | Phase 2 | Completed | Johns Hopkins University | Depressive Symptoms, Anxiety, Cancer | Apr 1, 2007 |
| Neurological Influences on Drug Prevention Intervention | Psilocybin | Phase 1 / Phase 2 | Completed | University of Florida | Youths At-risk for Drug Use/Abuse | Jan 1, 2005 |
| Youth Drug Abuse Family and Cognitive-Behavioral Therapy | Psilocybin | Phase 2 | Completed | University of Florida | Drug Abuse | Jan 1, 2005 |
| Effects of Psilocybin in Advanced-Stage Cancer Patients With Anxiety | Psilocybin | Phase 1 / Phase 2 | Completed | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | Anxiety | Apr 1, 2004 |