Substance use disorder is one of the fastest-growing areas of psychedelic research. Psilocybin has shown promise in alcohol and tobacco use disorder, while ibogaine is being studied for opioid dependence and withdrawal. This page collects every addiction-related psychedelic trial PoliPsy tracks, with phase, sponsor, and recruitment status.
| Trial | Drug | Phase | Status | Sponsor | Conditions | Start date |
|---|---|---|---|---|---|---|
| Safety Profile of Psilocybin for Cocaine Use Disorder | Psilocybin | Early Phase 1 | Suspended | University of California, Los Angeles | Cocaine Use Disorder | Feb 1, 2029 |
| Inpatient Buprenorphine Induction With Psilocybin for Opioid Use Disorder | Psilocybin | Phase 2 | Withdrawn | Johns Hopkins University | Opioid Use Disorder | Apr 1, 2027 |
| Psilocybin for Methamphetamine Use Disorder | Psilocybin | Phase 2 | Not Yet Recruiting | Peter Hendricks | Methamphetamine Use Disorder | Feb 1, 2027 |
| Psilocybin-Assisted Psychotherapy for the Treatment of Severe Alcohol Use Disorder | Psilocybin | Phase 2 | Not Yet Recruiting | Brigham and Women's Hospital | Alcohol Use Disorder | Nov 15, 2026 |
| Psilocybin Therapy for Methamphetamine Use Disorder and HIV | Psilocybin | Phase 2 | Not Yet Recruiting | Nicky Mehtani, MD, MPH | Methamphetamine Use Disorder, Human Immunodeficiency Virus (HIV) | Nov 1, 2026 |
| Feasibility of Incorporating a Standardized Substance Use Measure With Linked-Brief Intervention Into Routine Psychosocial Care of Adult Childhood Cancer Survivors | Psilocybin | N/A | Recruiting | St. Jude Children's Research Hospital | Survivors of Childhood Cancer, Substance Use | Oct 1, 2026 |
| Psilocybin With Psychotherapy for Improving Chronic Pain in Cancer Patients Requiring Opioids | Psilocybin | Phase 2 | Not Yet Recruiting | Roswell Park Cancer Institute | Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm | Sep 15, 2026 |
| QAIAx (AIhealth4U) - AI Public Health Central: Microcity-A (re Quantum AI Agency Aka AI City Hall Project, UPSTO App Nos. 64/074,526, 64/063,557, 63/903,181, 63/729,428 | Multiple | N/A | Not Yet Recruiting | Veterans Recovery Network Inc. | Asperger's Disorder, Asperger Disorder, Autism Disorder, Autism, ADHD - Attention Deficit Disorder With Hyperactivity, ADHD, ASD, Alcohol Abuse/Dependence, Alcohol Addiction, Alcohol and Other Drug Use Disorders, Alcohol and Other Substance Use Prevention, Gambling Addiction, Gambling Disorder, Sex Abuse, Sex Behavior, Sex Crimes, Sex Disorder, Sex Disorders, Gender Dysphoria, Adult, Eating Behavior Disorders, Narcotic-Related Disorders, Narcotic Addiction, Narcissism, Psychiatric Disorder, Psychedelic Effects in Healthy Volunteers, Psychedelic Experiences, Psychedelic Drug Dependence, Marijuana Use Disorder, Marijuana Abuse and Dependence, Smoking (Tobacco) Addiction, Smoking Among Youth, Smoking Abstinence, Abstinence, Sex, Opiate Substitution Treatment, Opioid Abuse (Disorder), Opioid Abuse and Addiction, Cocaine Abuse, MDMA ('Ecstasy'), Addiction Disorders, Homeless and Low Incomes People, Refugees, Homelessness, Reliability and Validity, Anger Problems, Child Abuse, Sexual | Sep 1, 2026 |
| Evaluating the Efficacy of a Vocational Counseling Intervention to Improve Occupational Functioning and Employment Quality Among Veterans With Mental Health and Substance Use Disorders | Psilocybin | N/A | Recruiting | VA Office of Research and Development | Unemployment | Sep 1, 2026 |
| Neurobehavioral Mechanisms of Psilocybin-assisted Treatment for AUD | Psilocybin | Phase 2 | Recruiting | NYU Langone Health | Alcohol Use Disorder | Sep 1, 2026 |
| Psilocybin Assisted Psychotherapy for Treatment Resistant Depression and Co-occurring Substance Use Disorder | Psilocybin | Phase 1 / Phase 2 | Not Yet Recruiting | Indiana University | Treatment Resistant Depression, Substance Use Disorders | Aug 1, 2026 |
| MDMA-Assisted Therapy for Veterans With PTSD and Alcohol Use Disorder | MDMA | Phase 2 / Phase 3 | Recruiting | VA Office of Research and Development | Post Traumatic Stress Disorder, Alcohol Use Disorder | May 18, 2026 |
| Nen ŨnkUmbi/EdaHiYedo Plus (We Are Here Now Plus): a Multi-level Intervention to Reduce Health Disparities Among American Indian Youth | Psilocybin | N/A | Recruiting | Montana State University | Healthy, Condom Use, Mental Health, Substance Use (Drugs, Alcohol) | Mar 23, 2026 |
| Evaluation of Tirzepatide as an Adjunct to Buprenorphine for the Treatment of Opioid Use Disorder | Psilocybin | Phase 2 | Recruiting | T. John Winhusen, PhD | Opioid Use Disorder, Opioid Use Disorder, Moderate, Opioid Use Disorder, Severe | Jan 29, 2026 |
| Psilocybin on Brain Mechanisms of Motivation in OUD | Multiple | Phase 2 | Recruiting | University of Pennsylvania | Opioid Use Disorder | Dec 22, 2025 |
| Psilocybin for Opioid Use Disorder (OUD) | Psilocybin | Phase 2 | Recruiting | NYU Langone Health | Opioid Use Disorder | Dec 17, 2025 |
| Wellcome Leap Psilocybin for OUD | Multiple | Phase 2 | Recruiting | Anna Rose Childress, Ph.D. | Opioid Use Disorder | Oct 7, 2025 |
| Psilocybin and Methylenedioxymethamphetamine (MDMA) for Post-traumatic Stress Disorder (PTSD) | Multiple | Phase 1 | Recruiting | Johns Hopkins University | Posttraumatic Stress Disorder | Sep 17, 2025 |
| Mapping Ibogaine Neural Dynamics in Opioid Use Disorder | Ibogaine | N/A | Recruiting | University of California, Irvine | Opioid Use Disorder (OUD) | Sep 8, 2025 |
| The Potential Therapeutic Effects of Psychedelic, N, N-dimethyltryptamine (DMT), on Alcohol Use Disorder (AUD) | Multiple | Phase 1 | Recruiting | Yale University | Alcohol Use Disorder (AUD), Alcohol-Related Disorders, Alcohol Use | Aug 4, 2025 |
| Psilocybin or Ketamine for Alcohol Use Disorder: An Active Comparator Trial | Psilocybin | Phase 2 | Recruiting | University of Iowa | Alcohol Use Disorder, Alcohol Dependence, Alcohol Abuse | Jun 12, 2025 |
| Psilocybin With Psychological Support (Psi-PS) for Military Veterans and First Responders With Co-occurring PTSD & Alcohol Use Disorder (AUD) | Psilocybin | Phase 2 | Active Not Recruiting | Nathan Brashares Sackett | Alcohol Use Disorder (AUD), PTSD | Jun 1, 2025 |
| Exploration of Synaptotrophic Effects of Psilocybin in Opioid Use Disorder (OUD) | Psilocybin | Phase 1 | Recruiting | Yale University | Opioid Use Disorder | May 28, 2025 |
| Gathering Online for Dialogue and Discussion to Enhance Social Support | Psilocybin | N/A | Recruiting | RTI International | Alcohol Misuse, HIV, Sexually Transmitted Infections, Pre-exposure Prophylaxis | Apr 7, 2025 |
| Psilocybin for Methamphetamine Addiction | Psilocybin | Early Phase 1 | Recruiting | Kevin Murnane | Methamphetamine Use Disorder | Apr 4, 2025 |
| Observational Pilot Study to Explore the Social and Health Impacts of a New Model of Care in Oregon: Psilocybin Services on Alcoholism | Psilocybin | N/A | Active Not Recruiting | Healing Advocacy Fund | Alcohol Use Disorder | Mar 5, 2025 |
| Ketamine-Assisted Recovery for Methamphetamine Use Disorder & HIV | Psilocybin | Phase 2 | Completed | Nicky Mehtani, MD, MPH | Methamphetamine Use Disorder | Mar 4, 2025 |
| Sensing Physiological Symptoms of Opioid Withdrawal and Cravings in Patients With Opioid Use Disorder | Psilocybin | N/A | Recruiting | Spark Biomedical, Inc. | Opioid Withdrawal, Opioid Use Disorder | Feb 19, 2025 |
| Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics | Multiple | N/A | Terminated | Yale University | OCD, Major Depressive Disorder (MDD), Alcohol Use Disorder (AUD), Healthy Volunteer, Migraine, PTSD, PTSD - Post Traumatic Stress Disorder, Addiction, Tobacco Use Disorder, Obsessive Compulsive Disorder (OCD), Opioid Use Disorder | Dec 12, 2024 |
| Open-Label Psilocybin Study in Transdiagnostic Population | Psilocybin | Phase 1 | Recruiting | Yale University | Transdiagnostic, Depression - Major Depressive Disorder, Anxiety, PTSD Symptoms, PTSD, Substance Use, Substance Use Disorder (SUD), OCD | Oct 17, 2024 |
| Psilocybin in Cancer Pain Study | Psilocybin | Phase 2 | Recruiting | Yvan Beaussant, MD, MSci | Opioid-Related Disorders, Pain Management, Pain Management and Care, Advanced Cancer, Advanced Cancers | Sep 23, 2024 |
| Couples Motivational Interviewing to Reduce Drug Use and HIV Risk in Vulnerable Male Couples | Psilocybin | N/A | Recruiting | Hunter College of City University of New York | Substance Use, HIV Infections | May 25, 2024 |
| Building Social and Structural Connections for the Prevention of Opioid Use Disorder Among Youth Experiencing Homelessness | Psilocybin | N/A | Recruiting | Ohio State University | Opioid Use Disorder, Dual Diagnosis, Housing Problems, Mental Disorder in Adolescence, Risk Behavior, Homelessness | May 6, 2024 |
| Mindful Self-Compassion to Address PTSD and Substance Use in Unhoused Women | Psilocybin | N/A | Completed | University of California, Los Angeles | Posttraumatic Stress Disorder (PTSD), Anxiety, Depression - Major Depressive Disorder | May 5, 2024 |
| MDMA for Co-occurring PTSD and OUD After Childbirth | Multiple | Phase 2 | Recruiting | University of New Mexico | Stress Disorders, Post-Traumatic, Opioid Use Disorder | Apr 16, 2024 |
| Outpatient Buprenorphine Induction With Psilocybin for Opioid Use Disorder | Psilocybin | Phase 2 | Recruiting | Johns Hopkins University | Opioid Use Disorder | Feb 8, 2024 |
| MDMA for AUD/PTSD Comorbidity | MDMA | Phase 2 | Completed | Carolina L Haass-Koffler | Alcohol Use Disorder, Post Traumatic Stress Disorder | Feb 6, 2024 |
| Psilocybin-Assisted vs Ketamine-Assisted Psychotherapy for Alcohol Use Disorder | Psilocybin | Phase 2 | Active Not Recruiting | Peggy C Nopoulos | Alcohol Use Disorder | Feb 2, 2024 |
| 5-HT2A Agonist Psilocybin in the Treatment of Tobacco Use Disorder | Psilocybin | Phase 2 | Recruiting | Johns Hopkins University | Tobacco Use Disorder | Nov 1, 2023 |
| Test of the Better Together Intervention | Psilocybin | N/A | Completed | Johns Hopkins Bloomberg School of Public Health | Substance Use | Sep 1, 2023 |
| Alcohol Misuse, Gut Microbial Dysbiosis and PrEP Care Continuum: Application and Efficacy of SBIRT Intervention | Psilocybin | N/A | Recruiting | Shirish S Barve | Alcohol Use Disorder, Risk Behavior, Health, Dysbiosis, HIV Infections | Aug 1, 2023 |
| Peer Recovery to Improve Polysubstance Use and Mobile Telemedicine Retention | Psilocybin | N/A | Recruiting | University of Maryland, College Park | Polysubstance Addiction, Opioid Medication Assisted Treatment, Treatment Adherence, Retention in Care, Substance-Related Disorders | Jun 15, 2023 |
| Telemedicine for Unhealthy Alcohol Use in Persons Living With HIV Using CETA | Psilocybin | N/A | Active Not Recruiting | University of Alabama at Birmingham | Hiv, Alcohol Problem | May 4, 2023 |
| Effectiveness of an Evidence-based Stepped Care System for Alcohol and Other Drug Use Problems Among Congolese Refugees in Zambia | Psilocybin | N/A | Completed | Columbia University | Alcohol and Substance-Related Mental Disorders | Apr 26, 2023 |
| Study of the Safety and Feasibility of Psilocybin in Adults With Methamphetamine Use Disorder | Psilocybin | Phase 1 | Terminated | University of Wisconsin, Madison | Methamphetamine Use Disorder, Substance-Related Disorders, Chemically-Induced Disorders, Substance Use Disorders, Stimulant-Use Disorder | Mar 3, 2023 |
| Psilocybin-Enhanced Psychotherapy for Methamphetamine Use Disorder | Psilocybin | Phase 1 / Phase 2 | Active Not Recruiting | Portland VA Research Foundation, Inc | Amphetamine-Related Disorders | Jul 7, 2022 |
| Delivering Transcutaneous Auricular Neurostimulation to Improve Relapse Prevention in Opioid Use Disorder | Psilocybin | N/A | Completed | Spark Biomedical, Inc. | Opioid-use Disorder, Opioid Withdrawal | May 27, 2022 |
| Addressing Risk Through Community Treatment for Infectious Disease and Opioid Use Disorder Now (ACTION) Among Justice-involved Populations | Psilocybin | N/A | Completed | Yale University | Opioid Use Disorder, Infectious Disease, Risk Reduction Behavior, Substance Use, Substance Abuse, Stimulant Use Disorder | Mar 31, 2022 |
| Expanding the Potential of Couples HIV Testing: Adjunct Modules to Reduce Drug Use Among Vulnerable Male Couples | Psilocybin | N/A | Active Not Recruiting | Hunter College of City University of New York | Substance Use, HIV Infections | Oct 13, 2021 |
| Psilocybin Treatment of Major Depressive Disorder With Co-occurring Alcohol Use Disorder | Psilocybin | Phase 2 | Active Not Recruiting | Johns Hopkins University | Major Depressive Disorder, Alcohol Use Disorder | Apr 14, 2021 |
| iSTART: A Campus & Community Initiative for Services in Tec-health | Psilocybin | N/A | Completed | California State University, Northridge | Substance Use, Binge Drinking, Marijuana Use, Alcohol Drinking, Prescription Opioid Misuse, Illicit Drug Use | Feb 20, 2021 |
| Pilot Trial of Visual Healing® in Psilocybin-assisted Therapy for Alcohol Use Disorder | Psilocybin | Phase 2 | Active Not Recruiting | Keith Heinzerling | Alcohol Use Disorder | Feb 18, 2021 |
| Adjunctive Effects of Psilocybin and a Formulation of Buprenorphine | Psilocybin | Phase 1 | Recruiting | University of Wisconsin, Madison | Opioid Use Disorder | Jan 13, 2021 |
| Therapy and Peer Support for Patients Taking Medication for Opioid Use Disorder | Psilocybin | N/A | Active Not Recruiting | Philadelphia College of Osteopathic Medicine | Opioid Use Disorder | Jul 15, 2020 |
| HIV+ Substance Users Released From Jail | Psilocybin | N/A | Completed | University of Texas Southwestern Medical Center | HIV/AIDS, Substance Use Disorders | May 29, 2019 |
| Project PRIDE (Promoting Resilience In Discriminatory Environments) | Psilocybin | N/A | Completed | University of Houston | Human Immunodeficiency Virus, Sexually Transmitted Infections, Anxiety, Depression, Substance Use Disorders | Nov 9, 2018 |
| Effectiveness & Implementation of a Behavioral Intervention for Adherence and Substance Use in HIV Care in South Africa | Psilocybin | N/A | Completed | University of Maryland, College Park | Human Immunodeficiency Virus, Alcohol-Related Disorders, Drug Use | Jul 30, 2018 |
| Harnessing Placebo Effects in Methadone Treatment | Psilocybin | N/A | Completed | University of Maryland, Baltimore | Opioid-use Disorder, Opioid-Related Disorders | Dec 5, 2017 |
| Developing SUPPORT, a Community-Driven, Recovery-Oriented System of Care | Psilocybin | N/A | Completed | Indiana University | Substance Use | Oct 23, 2017 |
| Adolescents With Substance Use Disorders Transitioníng From Residential Treatment to the Community | Psilocybin | N/A | Completed | Brown University | Substance Use, Adolescent Behavior | Apr 1, 2017 |
| Buprenorphine and Substance Abuse Services for Prescription Opioid Dependence | Psilocybin | N/A | Completed | Kaiser Permanente | Opiate Substitution Treatment | Dec 1, 2015 |
| Understanding Substance Use and Incident HIV/STI Among Young Black MSM | Psilocybin | N/A | Completed | Emory University | HIV, Substance Abuse | Jul 1, 2015 |
| Psilocybin-facilitated Treatment for Cocaine Use | Psilocybin | Phase 2 | Completed | University of Alabama at Birmingham | Cocaine-Related Disorders | May 1, 2015 |
| Pilot Study of Entacapone for Methamphetamine Abuse | Psilocybin | Early Phase 1 | Completed | Oregon Health and Science University | Methamphetamine Dependence | Jun 1, 2014 |
| A Double-Blind Trial of Psilocybin-Assisted Treatment of Alcohol Dependence | Psilocybin | Phase 2 | Completed | NYU Langone Health | Alcohol Dependence | Jun 1, 2014 |
| Substance Use and Sexual Risk Reduction Intervention for Homeless Youth | Psilocybin | N/A | Completed | RAND | Substance Use, Sexual Risk Behavior | Jan 1, 2014 |
| Integrating Substance Abuse Assessment & Intervention in Primary Care Settings | Psilocybin | N/A | Completed | Treatment Research Institute | Drug Use, Alcohol Use | Jun 1, 2012 |
| A Study to Assess the Abuse Potential of Hydrocodone Extended-Release Tablet in Recreational Opioid Users | Psilocybin | Phase 1 | Completed | Cephalon | Drug Abuse | Mar 1, 2012 |
| Effects and Therapeutic Potential of Psilocybin in Alcohol Dependence | Psilocybin | Phase 2 | Completed | University of New Mexico | Alcohol Dependence | Jan 1, 2012 |
| Psychological Effects of Methylenedioxymethamphetamine (MDMA) When Administered to Healthy Volunteers | MDMA | Phase 1 | Completed | Resilient Pharmaceuticals | Psychological Effects of Study Drug | Apr 9, 2011 |
| Effects of MDMA on Social and Emotional Processing | MDMA | N/A | Completed | University of Chicago | Drug Addiction | Jul 1, 2010 |
| Impact of Group Motivational Interviewing and In-Home-Messaging-Devices for Dually Diagnosed Veterans | Psilocybin | N/A | Completed | VA Office of Research and Development | Alcohol Dependence, Dual Diagnosis, Drug Dependence | May 3, 2010 |
| Psilocybin-facilitated Smoking Cessation Treatment: A Pilot Study | Psilocybin | N/A | Completed | Johns Hopkins University | Nicotine Dependence | Sep 1, 2008 |
| Caffeine and Cocaine | Psilocybin | Phase 1 / Phase 2 | Completed | Virginia Commonwealth University | Cocaine Dependence | Apr 1, 2008 |
Psychedelic Clinical Trials for Depression · Psychedelic Clinical Trials for PTSD · Psychedelic Clinical Trials for Anxiety · All psychedelic clinical trials
Psilocybin leads research into alcohol and tobacco use disorder, ibogaine is studied for opioid dependence and withdrawal, and LSD and ayahuasca appear in smaller substance-use studies.
Randomized trials have reported reductions in heavy drinking days following supervised psilocybin sessions combined with psychotherapy. Larger confirmatory studies are ongoing, and psilocybin is not an approved treatment.
Ibogaine is a Schedule I substance in the United States and is not approved for treatment. Several states have funded ibogaine research initiatives — track their status on PoliPsy’s legislation pages.
Recruitment status is shown for every listing and refreshed from ClinicalTrials.gov. Filter for recruiting studies and open the source record for eligibility criteria and site contacts.
No. Psychedelic treatments for substance use disorder remain investigational, and trials typically require participants to remain engaged with conventional care. Nothing on PoliPsy is medical advice.